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Dr. Cabezas-Cornejo, René
Nombre de publicación
Dr. Cabezas-Cornejo, René
Nombre completo
Cabezas Cornejo, René Andrés
Facultad
Email
rene.cabezas@ucsc.cl
ORCID
19 results
Research Outputs
Now showing 1 - 10 of 19
- PublicationPurification of 1-butanol from rich and lean aqueous heteroazeotropic mixture by sponge-like ionic liquid process(Elsevier, 2025)
; ;Jaramillo, Karin; ;Monsalve, NicolasCastro-Muñoz, RobertoThe Acetone-Butanol-Ethanol (ABE) fermentation process is a promising approach for sustainable biobutanol production. However, separation and purification of butanol following membrane-based or distillation separation processes remain challenging due to the formation of a water-butanol heteroazeotropic mixture (55.5 wt% 1-butanol), requiring multiple distillation columns and generating both lean and rich aqueous phases. In this study, a novel sponge-like ionic liquid extraction process was employed to recover 1-butanol from these aqueous mixtures using 1-Methyl-3-octadecylimidazolium bis(trifluoromethyl sulfonyl)imide (C18MIM[Tf2N]). The liquid C18MIM[Tf2N] was contacted with a rich and lean butanol aqueous phases at temperatures above IL´s melting point (60 °C to 90 °C) and an IL/aqueous ratio of 1:1. After phase separation, the IL solidified at room temperature, allowing the extraction of the dissolved component via centrifugation. The results indicated that optimal recovery from the lean phase occurred at 80 °C, achieving enhanced solubility of 1-butanol in the IL while minimizing losses. Under these conditions, the remaining aqueous phase contained only 1 wt% 1-butanol, and over 95 % of the butanol was recovered from the IL. For the rich phase, high butanol concentrations altered the hydrophobicity of C18MIM[Tf2N], causing water retention and resulting in an aqueous phase with a higher butanol content. These findings highlight the potential of sponge-like IL extraction for efficient butanol purification, reducing energy-intensive distillation steps. - PublicationDevelopment of an asymmetric cellulose acetate-ionic liquid P6,6,6,14[PHOS] gel membrane for the perstraction of succinic acid from a model fermentation solution of yarrovia lipolytica(Elsevier, 2024)
; ;Zurob, Elsie ;Quijada-Maldonado, Esteban ;Castro-Muñoz, Roberto ;Romero, JulioPlaza, AndreaThis study introduces a novel approach to separate succinic acid (SA) from fermentation mixtures using an asymmetric membrane based on the gelation of the ionic liquid [P6,6,6,14][PHOS] coated with two layers of cellulose acetate. The membrane was designed to explore the synergistic effect of polymer-ionic liquid interfaces according to the solution-diffusion theory. The gelation of the ionic liquid was achieved using 12-hydroxystearic acid at a concentration of 1.5%, allowing the use of ionic liquid gels as new materials for the generation of membranes. The perstraction performance of the membrane was evaluated over 5 h at two different temperatures (25◦C and 37◦C), with an initial feed solution concentration of 50 kg m− 3 for SA and glycerol and pure water as a receiving phase., Several flow rates and phase-volume ratios were studied anda mass transfer model based on the resistance-in-series theory was assessed to understand the behavior of each mass transfer stage considering the distribution in each interphase. Interestingly, optimal perstraction results were obtained at 37◦C, with an average transmembrane flux of 0.22 kg m-2h− 1 for SA, an extraction percentage of 43.1% for SA and 0.7% for glycerol, and a SA/glycerol selectivity of 54.98. Besides presenting a novel composite membrane, this study reports pioneering perstraction outcomes, highlighting its potential as an innovative SA separation strategy and structured new materials for selective extractions. - PublicationMangiferin: A comprehensive review on its extraction, purification and uses in food systemsWith the target of fabricating healthier products, food manufacturing companies look for natural-based nutraceuticals that can potentially improve the physicochemical properties of food systems while being nutritive to the consumer and providing additional health benefits (biological activities). In this regard, Mangiferin joins all these requirements as a potential nutraceutical, which is typically contained in Mangifera indica products and its by-products. Unfortunately, knowing the complex chemical composition of Mango and its by-products, the extraction and purification of Mangiferin remains a challenge. Therefore, this comprehensive review revises the main strategies proposed by scientists for the extraction and purification of Mangiferin. Importantly, this review identifies that there is no report reviewing and criticizing the literature in this field so far. Our attention has been targeted on the timely findings on the primary extraction techniques and the relevant insights into isolation and purification. Our discussion has emphasized the advantages and limitations of the proposed strategies, including solvents, extracting conditions and key interactions with the target xanthone. Additionally, we report the current research gaps in the field after analyzing the literature, as well as some examples of functional food products containing Mangiferin.
- PublicationPEBAX polymer inclusion hydrophobic deep eutectic solvent membranes for pervaporation of biobutanol: Mass transfer and COSMO-RS analysis(Elsevier, 2024)
; ;González-Revuelta, D. ;Zurob, E. ;Olea, F. ;Quijada-Maldonado, E.Gorri, D.Deep Eutectic Solvent(DES) and specifically Hydrophobic Deep Eutectic Solvents (HDES) are considered a relatively novel class of solvents, which show good features to include them in pervaporation membranes. Polymer inclusion HDES membranes offer a separation media, which shows a faster molecular diffusion than polymeric membranes, combining the best properties of liquid and polymer membranes, such a high selectivity with high burst pressure and durability. The aim of this work focuses on the development of different PEBAX/ lidocaine-thymol [2:1] (Lidol HDES) membranes by the temperature-induced phase-inversion technique to be used in the pervaporation process to recover butanol from ABE model solution. The mass transfer modeling through the membrane using the resistances-in-series approach was implemented to find the mass transfer resistance distribution. The polymer inclusion membranes showed improved results for the butanol/water selectivity compared to the single PEBAX membrane used as a reference. The flux of butanol obtained with the 30 % w/w Lidol HDES membrane was 0.112 kg m− 2 hr− 1. The flux of water was 0.445 kg m− 2 hr− 1 showing a selectivity value for butanol/water of 20 % bigger than single PEBAX membrane. The improvement in the selectivity can be explained by the synergic effect of the HDES in the membrane. After use, the polymer inclusion membrane consistently demonstrated a stable performance in effectively separating butanol from the ABE solution. It was seen that the overall resistance decreases as the liquid flow rate increases; regarding the liquid side resistance, it becomes important at smaller flow rates and is almost negligible for turbulent regimen. - PublicationA review towards selective cobalt recovery in solvent extraction: Potential of ionic liquids as diluents and extractants(Elsevier, 2024)
; ;Olea, Felipe ;Estay, Humberto ;Jofré-Ulloa, Pedro ;Merlet, Gastón ;Araya, Alejandro ;Romero, JulioQuijada-Maldonado, EstebanCobalt (Co) stands out as one of the most critical metals in contemporary use, particularly due to its increasing demand in technological products and especially in electromobility. Over the years, ionic liquids (ILs) have provided a green alternative to volatile organic solvents in hydrometallurgy due to their outstanding properties, such as the negligible vapor pressure and their increased selectivity provided in separation processes, which opens the possibility to ramp up the Co-production while maintaining sustainable mining processes. Thus, this review offers a complete comprehensive and critical summary of published works on the use of ILs in the hydrometallurgy of Co, starting from the leaching from a primary source by conventional methods and then, from the pregnant leach solution (PLS) focuses on the advantages and disadvantages of solvent extraction (SX) in different aqueous media (chlorinated, nitrated, and sulfated) in which ILs are used to separate selectively Co from a multi-metal mixture. In the following section, its recovery from the loaded organic phase by acid stripping is discussed. Finally, this review provides the challenges that ILs should overcome to be viable for large-scale industrial applications and the opportunities that exhibit for selective recovery of Co from PLS capitalizing. - PublicationIn-situ recovery of butanol from ABE fermentation solution by hydrophobic ionic liquid perstraction in tubular membranes assisted with vacuum(Separation and Purification Technology, 2023)
;Merlet, G. ;Becerra, J. ;Zurob, E. ;Plaza, A. ;Romero, J. ;Quijada-Maldonado, E. ;Pino-Soto, L.The selective removal of butanol from a fermentation broth continues to be a challenge for the generation of alternative biofuels. In this work, a continuous extraction of a model acetone-butanol-ethanol (ABE) solution, using a perstraction membrane system with ionic liquid [omim][Tf2N] as extractant phase coupled to a vacuum extraction system of the extractant phase has been studied. Perstraction assays were carried out using a tubular polydimethylsiloxane (PDMS) membrane to quantify the extraction percentage and transmembrane fluxes of butanol, acetone, ethanol, and water. The results indicate that the transmembrane fluxes of butanol were particularly high considering that the PDMS membrane used in the experiments was relatively thick (3.175 mm). The highest average flux of butanol was obtained at 37 °C using [omim][Tf2N] as extractant reaching a value of [kg h−1 m−2] with a separation performance showing a highest butanol/water selectivity value equal to 6.73. The mass transfer model based on the resistance-in-series theory, demonstrated a good correlation to the experimental data verifying that the membrane generates a higher resistance to mass transfer (∼98 %). This perstraction technique combined with the use of ILs could allow to design a wide range of separation processes to purify a large variety of molecules. Additionally, the perstraction process could be considered a good alternative for the selective separation of fermentation or reaction products with high commercial value. - PublicationHydrophobic eutectic solvents for the selective solvent extraction of molybdenum (VI) and rhenium (VII) from a synthetic pregnant leach solution(Journal of Molecular Liquids, 2023)
;Olea, Felipe ;Valenzuela, Matías ;Zurob , Elsie ;Parraguez, Benjamín ;Abejón, Ricardo; ;Merlet, Gastón ;Tapia, Ricardo ;Romero, JulioQuijada-Maldonado , Esteban.In this work, a study on the selective solvent extraction (SX) of molybdenum (Mo) and rhenium (Re) from a synthetic pregnant leach solution (PLS) has been carried out using nine different hydrophobic eutectic solvents (HES). Experiments were carried out using pure HES to evaluate the selective extraction and the subsequent stripping of these metal ions; then, the best HES was dissolved in kerosene to study the SX stoichiometry. Results indicated that only TOPO-based and N8881-Cl-based HES did not form emulsions, third phases or precipitates. These HES achieved a selective extraction because these obtained almost a 100% extraction towards Mo and Re from the PLS and very low extractions for Copper (Cu) and Iron (Fe) in one equilibrium stage. The stripping experiments showed that 95% of Mo and 22% of Re were stripped out from the loaded TOPO-based HDES, respectively, opening the possibility for the selective stripping of the metal species for further purification. Finally, the extraction stoichiometry was proposed based on an experimental slope analysis and the measurement of cations and anions transferred into the aqueous phase in which HES acts as a neutral extractant in the complexation of the Mo and Re salts. These promising results suggest that HES could be attractive for more sustainable mining industry. - PublicationDevelopment of PLA suture materials by extrusion, electrospinning and supercritical CO2 impregnation of ibuprofen and naproxen(The Journal of Supercritical Fluids, 2023)
;Rivera,Patricia ;Villegas, Carolina; ;Pérez, Barbara ;Torres, Alejandra ;López de Dicastillo, Carol ;Garrido, Luan ;Galvez, Paula ;Araya ,ClaudioRomero, JulioSuture materials based on poly (lactic acid) (PLA) were developed by means of two different methods: extrusion and electrospinning, which were followed by a supercritical CO2 impregnation treatment. Both suture materials obtained by these techniques were impregnated with naproxen and ibuprofen using supercritical CO2 as impregnation medium. The impregnation assays were carried out at two different pressures (12 and 15 MPa), a temperature of 40 °C and, a depressurization rate of 1 MPa/min. Depending on the drugs incorporated into the suture materials, the concentrations varied from 5.60 to 26.73 wt%. The addition of both drugs and, the preparation process itself caused different changes in the structural and thermal properties of the final suture materials. Finally, tests to quantify the kinetic release of both drugs were carried out in vitro by using a Franz diffusion cell, obtaining the concentration profiles of delivered compounds as a function of the time. - PublicationAnalysis of microwave-assisted heating and water extraction from imidazolium and phosphonium based ionic liquids(Thermochimica Acta, 2022)
; ;Araya-López, Claudio ;Carrera, Pedro ;Torres, Alejandra ;Pino-Soto, Luis ;Quijada-Maldonado, Esteban ;Merlet, Gastón ;Romero, JulioPlaza, AndreaIonic liquids have attracted widespread attention due to their low melting points, low vapor pressure, and non-flammability. However, their application at industrial scale is uncommon due to high costs and low recovering efficiency of the ionic liquids within the process. To reduce the costs and environmental effects of ionic liquids, this study proposes to use industrial microwave irradiation to recover eight different ionic liquids from water. The heating kinetics and identification between dielectric and convective heat properties were studied. Imidazolium-based ionic liquids showed the best results, reaching higher temperatures in shorter periods of time. Ionic liquid (bis(trifluoromethylsulfonyl) trihexyl(tetradecyl) phosphonium imide ([P6,6,6,14][Tf2N]) reached a temperature of 398 K in 360 s). On the other hand, the ionic liquid (1-butyl-3-methylimidazolium methylsulfate ([bmim][CH3OSO3]) reached a temperature of 417 K in 150 s). the ionic liquid Microwave heating experiments (water/ionic liquids) demonstrated a 90% recovery in ∼200 s for 1-octyl-3-methylimidazolium chloride ([omim][Cl]). Finally, the time used to heat-up ionic liquids with microwave irradiation was 15 times shorter than the time employed with vacuum-assisted distillation. Therefore, microwave-assisted heating has shown to be an excellent form to heat ionic liquids to decrease the cost of the extraction process and improve their reusability. - PublicationRhenium(VII) extraction from sulfuric aqueous solutions using ionic liquids as diluent and extractant: Insights on the extraction stoichiometry and process parameters(Wiley, 2022)
; ;Quijada‐Maldonado, Esteban ;Román, Rodrigo ;Merlet, Gastón ;Pérez, Bárbara ;Tapia, Ricardo ;Olea, Felipe ;Villarroel, Eduardo ;Araya‐López, ClaudioRomero, JulioBackground: Rhenium(Re) is a highly valuable metal recovered from molybdenite leach liquors by solvent extraction (SX) using toxic organic solvents. This work proposes an extracting phase free of volatile organics composed by the ionic liquid (IL) trioctylmethylammonium benzoate [TOMA][BA] as the extractant, due to its ability to extract Re(VII), and the IL 1‐octyl‐3‐methylimidazolium bis(trifluoromethylsulfonyl)imide [omim][Tf2N] as the diluent, due to its high hydrophobicity where the extraction stoichiometry and process parameters such as the initial pH, the extractant concentration in the diluent and stripping using ammonium hydroxide () and sodium hydroxide () were assessed. Results: This extracting phase yielded high extraction percentages: 95% with only 3% (v/v) of [TOMA][BA] in [omim][Tf2N]. A detailed study of the SX stoichiometry was carried out through slope analysis, showing that the SX occurs in two steps: first, the extraction of acid; then, the extraction of the metal ion via anion exchange with the transfer of IL‐diluent anion to the aqueous phase. Additionally, the extracting phase was tested in a synthetic molybdenite leached pregnant leach solution, showing selectivity towards Re(VII) over Cu(II) and Fe(III) at very low extractant concentration. The stripping of Re(VII) from the loaded phase was also studied achieving 60% stripping in only one equilibrium step when using . Conclusion: This novel extracting phase, free of volatile organic, shows promising Re(VII) extraction for future industrial applications.