The special issue of Technological and Economic Development of Economy entitled “Modelling and Simulation in Business, Economics and Management” presents extended versions of papers presented at the International Conference on Modelling and Simulation in Engineering, Economics and Management (MS’18 Mazatlán). The edition of the conference was hosted by the University of Occidente, Mexico. More than 100 authors and 50 papers concerning different topics of modelling and simulation in a wide range of areas were presented. The aim of the special issue is to present high quality papers in the area of modelling and simulation in business, economics and management. The main reason is that enterprises usually need to deal with complex and uncertain environments. In order to maximize as much as possible their management. After the reviewing process, five papers have been selected for publication in this special issue that is divided in two sections that are explained as follows.