• Home
  • UCSC journals portal
  • ANID repository
  • UCSC Thesis Repository
  • English
  • Español
  • Log In
    Have you forgotten your password?
  1. Home
  2. Productividad Científica
  3. Publicaciones Científicas
  4. Lanthanum-doped carbon dots for anticancer drug transport
 
Options
Lanthanum-doped carbon dots for anticancer drug transport
Dra. Núñez-Bernal, Dariela 
Facultad de Ciencias 
Ramasamy, Sivaraj
Facultad de Ciencias 
Joy-Williams, Monisha
Raboni-Grace, Sudhaker
Manikantan, Varnitha
Alexander, Aleyamma
Sri Varalakshmi, Govindaraj
Sumohan Pillai, Archana
Enoch, Israel
10.1016/j.matlet.2023.135540
Elsevier
2024
Herein, we report lanthanum-doped carbon dots for delivering the anticancer drug camptothecin. The carbon dots are made as a nanocomposite with a β-cyclodextrin-polyethylene glycol-folate polymer. XRD shows a typical reflection of carbon dots (002). The size of the carbon dot composite is 10.19 nm. XPS shows peaks at 830 and 850 eV, characteristic of lanthanum doped in the carbon dots. The material is superparamagnetic with a saturation magnetization of 0.28 emu/g. The nanocomposite shows a broad absorption band with tail absorption in the near-infrared range. Further, the material shows a high camptothecin encapsulation efficiency above 90 % and a slow release for above 5 days. The in vitro anticancer effect of the drug-loaded nanocarrier is examined on MCF-7 cell lines, and the IC50 value is 1.92 µg mL− 1. The cell cycle arrest is analyzed using flow cytometry. The nanocarrier shows promising results as a drug delivery agent.
Nanoparticles
Carbon materials
Nanocomposites
Polymer
β-Cyclodextrin
Drug delivery
Historial de mejoras
Proyecto financiado por: