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Synthesis, chemical identification, drug release and docking studies of the Amlodipine–Chitosan nanobiopolymer composite
Ramirez-Tagle, Rodrigo
Salgado-Moran, Guillermo
Mendez-Luna, David
Correa-Basurto, José
Cardona-Villada, Wilson
Mendoza-Huizar, Luis H.
Journal of the Chilean Chemical Society
2021
A new amlodipine-chitosan nanocomposite was built using amlodipine nanoparticles as primary scaffolds by spontaneous emulsification, and its complete elucidation was performed by using several spectrometric techniques. Our results indicate that the amlodipine-chitosan nanocomposite has better solubility than amlodipine at pH 7.4 with a nearly all the drug substance dissolved (97%) by the final time-point measured. The docking study support the existence of intermolecular interactions are established between amlodipine and chitosan
Chitosan
Nanocomposite
Drug release properties
Docking studies