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Discordance between allelic and genotype frequencies for CD36 rs3211938 between Mexican mestizo samples: Sample bias, genotyping error, or microevolution?
Flores, Sergio
Roco Videla, Ángel Gerardo
Silva González, Omar
Nutrición Hospitalaria
2022
The article published by Martín-Márquez et al.shows evidence on the association between the GT CD36 rs3211938 genotype and high levels of glucose, ox-LDL, HDL-cholesterol, and IR, and increased BMI in Mexican mestizo T2DM (type-2 diabetes mellitus) patients from western Mexico. The criteria used to define “mestizo” allow further research to survey those statistical associations in other Latin American mestizo populations. The cited work did not address the Hardy-Weinberg (H-W) equilibrium to contrast the concordance between allelic and genotype frequencies under the null hypothesis of absence of evolutionary factors operating on populations. The H-W test has been used to detect sampling bias and genotyping errors. In addition, the allelic and genotype frequencies were not contrasted with data reported by other studies.
Alleles
CD36
Antigens
Gene Frequency
Genotype
Humans
Mexico
Polymorphism
Single Nucleotide
Ciencias de la salud