Choosing a model that suitably represents the characteristics of a watershed to simulate low flows is crucial, especially in watersheds whose main source of baseflow generation depends on groundwater storage and release. The goal of this investigation is to study the performance and representativeness of storage-release process modeling, considering aspects such as the topography and geology of the modeled watershed through regional sensitivity analysis, in order to improve low-flow prediction. To this end, four groundwater storage-release structures in various watersheds with different geological (fractured and sedimentary rock) and topographic domains (steep and gentle slopes) were analyzed. The results suggest that the two-reservoir structure with three runoff responses is suitable (better) for simulating low flows in watersheds with fractured geological characteristics and rugged or steep topography. The results also indicate that a one-reservoir model can be adequate for predicting low flows in watersheds with a sedimentary influence or flat topography.