Entrepreneurship and technology have been strongly connected over the last decades. The growth of digital technology and external factors have brought entrepreneurs new opportunities and challenges. The COVID-19 pandemic has reevaluated the relationship between digitalization and innovative business models. Like any entrepreneurial process, entrepreneurs face a complex adaptation process that determines their success or failure. We reviewed 208 articles published in the past decade to identify trends related to the determinants and impacts of digital entrepreneurship pre- and post-COVID-19 pandemic. Our results show trends in the definitions used, the relationship between external and internal factors that enable the exploration of available digital technologies for emerging business models, and the value digital entrepreneurs create for social, economic, and technological developments. Our study proposes a multidimensional framework and discusses challenges and opportunities.