Steel buildings with tubular columns showed a satisfactory performance during the Honshu (2011) earthquake, unlike steel buildings in the 1994 Northridge and 1995 Kobe earthquakes, where welded moment connections showed damage in their joints. In this research, a lateral joint using a hollow structural section (HSS)-beam and HSS-column subjected to cyclic displacement was performed. Three large-scale specimens were tested and a numerical model was calibrated, reaching a good adjustment. Later, several configurations of beams and columns were evaluated using finite element (FE) models from the numerical model previously calibrated. A flexural resistance higher 0.80 Mp at 0.04 [rad] was obtained for all cases studied. The ductility factor in the 3 specimens was lower than 2.5, therefore a non-ductile behavior was controlled in the connection. This aspect is very important although a 0.8 Mp at 0.04 [rad] was achieved. Finally, the typical welded moment connection can be improved using the bolted moment connection, which allows the concentration of inelastic incursion in the beam compared with the welded solution. However, a non-ductile behavior derived from local buckling in flanges of a tubular beam can affect the seismic performance.