Digital technologies have a significant potential for collaboration, designing, and implementing better business initiatives. COVID-19 global lockdowns have increased the emergence of the Digital Social Entrepreneurship (DSE) phenomenon, which has been key in responding to social needs using digital technologies. The DSE scholarly discussion has been limited to a few studies. Therefore, little is known about theoretical foundations that explain the intersection between digital, social, and entrepreneurship. Based on an integrative literature review and a thematic case study, this study theorizes the micro-foundations of digital-social value-creation and explores the flourishment of the DSE phenomenon during/after the global lockdowns. Our findings contribute to the literature by extending the DSE definition and identifying the fostering (micro, meso, and macro) conditions involved in the digital-social value-creation process. Several implications emerged from the DSE learning, adaptation, and co-creation strategies/practices.