This paper presents a productive articulation model that serves as the basis for developing and enhancing regional innovation systems. The main objective is to generate a process of linkage between the industrial sector, academia, and government within which specifics regionals problems can be solves through the effective intervention of each of the actors. Also, a success story is present in the State Guanajuato, Mexico, which serves to visualize as a clear and defined process of articulation that allows between the actors a transfer of knowledge. Among the main results, be seen how the process proposed in the document serves to generate positive interaction between industry-academia-government, and in the present study solution feasible to the problem was obtained of the case.